VHL W117C (c.351G>X)

CI-VAR-00004673Explore in graph →CIViC 2470

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Von Hippel-Lindau Disease1unmapped disease
VHL W117C (c.351G>X)	(predisposing)	Predisposing	C	Supports Uncertain Significance	2	submitted	EID6658 The National Cancer Institute has a frozen tumour bank of ccRCC tumours that have been removed from VHL patients. One 60Y female patient with ccRCC was confirmed with a germline missense mutation (p.T… (full text at CIViC) PMID 27174753 · Fei et al., 2016 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.