VHL V87fs (c.259_260insA)

CI-VAR-00004660Explore in graph →NP_000542.1:p.Val87AspfsTer?NM_000551.3:c.259_260insACIViC 2432

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Von Hippel-Lindau Disease3unmapped disease
VHL V87fs (c.259_260insA)	(predisposing)	Predisposing	C	Supports Uncertain Significance	3	accepted	EID6506 Data was collected from 82 VHL mutation carriers in the Dutch VHL surveillance program. One patient was found with this insertion in the VHL gene. The patient was 42Y at the last follow-up and present… (full text at CIViC) PMID 24132471 · Kruizinga et al., 2014 · Open in CIViC	civic
VHL V87fs (c.259_260insA)	(predisposing)	Predisposing	C	N/A N/A	3	submitted	EID8479 All patients included in the study were VHL mutation carriers of 18 years or older examined between 1972 and 2012 in the VHL expertise centers Uni-versity Medical Center Groningen (UMCG) and Universit… (full text at CIViC) PMID 31087189 · van der Horst-Schrivers et al., 2019 · Open in CIViC

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.