Variant
VHL t(3;6)(p13;q25.1)
CI-VAR-00005066Explore in graph →CIViC 4008
Curated evidence
Evidence by cancer (2 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 20633763
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Von Hippel-Lindau Disease2unmapped disease | ||||||||
| VHL t(3;6)(p13;q25.1) | (predisposing) | Predisposing | C | Supports Predisposition | 2 | rejected | EID10350Two cases of germline translocations associated with the development of conventional RCCs are described. One was a 53-year-old male patient (case HA445-446) with constitutional t(3;6)(p13;q25.1) devel… (full text at CIViC) PMID 20633763 · Yusenko et al., 2010 · Open in CIViC | civic |
| VHL t(3;6)(p13;q25.1) | (predisposing) | Predisposing | C | Supports Predisposition | 3 | rejected | EID10357The proband presented with a large ulcer of the duodenum. Abdominal sonography and CT scan of the abdomen revealed bilateral solid masses, believed to represent RCC. Bilateral nephrectomy was performe… (full text at CIViC) PMID 2925273 · Kovacs et al., 1989 · Open in CIViC | |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available