Variant
VHL t(3;12)(q13.2;q24.1)
CI-VAR-00005063Explore in graph →CIViC 4009
Curated evidence
Evidence by cancer (2 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 20633763
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Von Hippel-Lindau Disease2unmapped disease | ||||||||
| VHL t(3;12)(q13.2;q24.1) | (predisposing) | Predisposing | C | Supports Predisposition | 2 | rejected | EID10351Two cases of germline translocations associated with the development of conventional RCCs are described. One was a 50-year-old male patient (HA359) carrying a germline t(3;12)(q13.2;q24.1) had only on… (full text at CIViC) PMID 20633763 · Yusenko et al., 2010 · Open in CIViC | civic |
| VHL t(3;12)(q13.2;q24.1) | (predisposing) | Predisposing | C | Supports Predisposition | 3 | submitted | EID10356A 50-year-old male patient was admitted with abdominal pain. CT found a tumor of the right kidney found to be clear cell renal cell carcinoma through histological findings. Chromosome analysis of the … (full text at CIViC) PMID 3422215 · Kovacs et al., 1988 · Open in CIViC | |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available