VHL Single Allele Deletion

CI-VAR-00004163Explore in graph →CIViC 3108

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Von Hippel-Lindau Disease2unmapped disease
VHL Single Allele Deletion	(predisposing)	Predisposing	C	N/A N/A	3	submitted	EID8499 Fourty-four of 389 patients with VHL (between 1988-1999) screened positive for PNETs either by pathologic analysis of tissue specimens or by characteristic radiographic appearance on CT and MRI. VHL g… (full text at CIViC) PMID 11114638 · Libutti et al., 2000 · Open in CIViC	civic
VHL Single Allele Deletion	(predisposing)	Predisposing	C	N/A N/A	3	submitted	EID8580 Two families where index patients had mosaic partents from the NIH-VHL Family Registry were reviewed. Family 1 had an index patient (III:1), a 27Y female, with hemangioblastoma found at 24Y old and pa… (full text at CIViC) PMID 10631138 · Sgambati et al., 2000 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.