Variant · Indel
VHL N150fs (c.447del)
CI-VAR-00002878Explore in graph →NP_000542.1:p.Asn150IlefsTer9NM_000551.3:c.447delCIViC 2561
Curated evidence
Evidence by cancer (2 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 7915601
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Kidney Carcinoma1 | ||||||||
| VHL N150fs (c.447del) | (oncogenic) | Oncogenic | C | Supports Oncogenicity | 1 | accepted | EID6918Tumors from 98 patients with sporadic clear cell renal carcinoma (ccRC) were analyzed for VHL mutations and loss of heterozygosity (LOH). Somatic VHL variants were observed in 56 patients, and VHL LOH… (full text at CIViC) PMID 7915601 · Gnarra et al., 1994 · Open in CIViC | civic |
| Von Hippel-Lindau Disease1unmapped disease | ||||||||
| VHL N150fs (c.447del) | (predisposing) | Predisposing | C | N/A N/A | 3 | submitted | EID8665The data of 18 patients with solid renal tumours associated with VHL disease were analyzed. All patients except for Patient 12 came from families with a definite VHL family history (the paper does not… (full text at CIViC) PMID 18067796 · | |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available