VHL L140fs*158 (c.419delT)

CI-VAR-00002243Explore in graph →NP_000542.1:p.Leu140ProfsTer19NM_000551.3:c.419delTCIViC 2559

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Kidney Carcinoma1
VHL L140fs*158 (c.419delT)	(predisposing)	Predisposing	C	Supports Uncertain Significance	3	submitted	EID6916 Tumors from 110 patients with sporadic renal carcinoma were analyzed for VHL mutations and loss of heterozygosity. 56 of the 98 samples from sporadic, clear cell renal carcinoma patients were identifi… (full text at CIViC) PMID 7915601 · Gnarra et al., 1994 · Open in CIViC	civic
Von Hippel-Lindau Disease1unmapped disease
VHL L140fs*158 (c.419delT)	(predisposing)	Predisposing	C	Supports Predisposition	3	submitted	EID9388 A cohort of VHL patients from the Greater Toronto Area in Canada were retrospectively reviewed. Patient ID 45 was found with this germline mutation and CNS hemangioblastoma. Whether patients were rela… (full text at CIViC)

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.