Variant · Insertion
VHL 106insR (c.316insGCC)
CI-VAR-00000021Explore in graph →CIViC 2930
Curated evidence
Evidence by cancer (2 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 11850829
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Von Hippel-Lindau Disease2unmapped disease | ||||||||
| VHL 106insR (c.316insGCC) | (predisposing) | Predisposing | C | Supports Predisposition | 3 | accepted | EID789236 VHL-related pheochromocytomas (from 21 patients) and 10 VHL-related CNS hemangioblastomas (from 6 patients) were studied using comparative genomic hybridization (CGH) to detect genetic imbalances. … (full text at CIViC) PMID 11850829 · Lui et al., 2002 · Open in CIViC | civic |
| VHL 106insR (c.316insGCC) | (predisposing) | Predisposing | C | N/A N/A | 3 | submitted | EID8406One patient of 17 presenting with VHL germline mutations presented with the 106insR (c.316insGCC) mutation. Single strand conformation polymorphism and southern blotting for variant identification in … (full text at CIViC) PMID 11309459 · Gläsker et al., 2001 · Open in CIViC | |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available