Variant · Expression
VEGFA Overexpression of VEGF121 and VEGF110
CI-VAR-00003259Explore in graph →CIViC 3325
Curated evidence
Evidence by cancer (4 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 23932548
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Malignant Breast Neoplasm3 | ||||||||
| VEGFA Overexpression of VEGF121 and VEGF110 | Bevacizumab | Predictive | B | Supports Sensitivity Response | 2 | submitted | EID9299Patients with high VEGF121and VEGF110 levels treated with bevacizumab and chemotherapy compared to chemotherapy only show a trend toward improved PFS. However this trend is not significant (HR 0.64; 9… (full text at CIViC) PMID 23932548 · Cameron et al., 2013 · Open in CIViC | civic |
| VEGFA Overexpression of VEGF121 and VEGF110 | Bevacizumab | Predictive | B | Supports Sensitivity Response | 4 | submitted | EID9300Patients with high VEGF121and VEGF110 levels treated with bevacizumab compared to placebo show a trend toward improved PFS (HR 0.64, 95% CI, 0.47 to 0.88). The trend was not significant for patients w… (full text at CIViC) PMID 27817944 · Miles et al., 2017 · Open in CIViC | |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available