VEGFA Overexpression of VEGF121

CI-VAR-00003258Explore in graph →CIViC 3324

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Glioblastoma1
VEGFA Overexpression of VEGF121	Bevacizumab	Predictive	B	Supports Resistance	4	submitted	EID9490 In a clinical study including 12 patients already treated with bevacizumab, high levels of plasma VEGF-121 decrease the OS and the PFS (p = 0.0246 and p = 0.0295) compared to low level of expression. PMID 29747600 · Martini et al., 2018 · Open in CIViC	civic
HER2 Negative Breast Cancer1unmapped disease
VEGFA Overexpression of VEGF121	Bevacizumab	Predictive	B	Supports Sensitivity Response	3	submitted	EID9297 Patients with high plasma VEGF121 levels treated with bevacizumab compared to placebo showed a trend toward improved PFS (HR 0.52; 95% CI, 0.33 to 0.81). The trend was not significant with patients wi… (full text at CIViC)

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.