Variant · Snv
TSC2 D1734E
CI-VAR-00000433Explore in graph →CIViC 3802
Curated evidence
Evidence by cancer (1 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 22903760
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Unmapped disease1unmapped disease | ||||||||
| TSC2 D1734E | (functional) | Functional | D | Supports Unaltered Function | 3 | submitted | EID10274Functional analysis of TSC2 variants showed that D1734E did not cause changes in the function of the TSC1-TSC2 complex, as measured by levels of TSC1, TSC2, S6K and phospho-S6K in an immunoblot assay.… (full text at CIViC) PMID 22903760 · Hoogeveen-Westerveld et al., 2013 · Open in CIViC | civic |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available
No ClinVar interpretation attached to this variant.