TP53 Y205C

CI-VAR-00004781Explore in graph →CIViC 5558

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease1unmapped disease
TP53 Y205C	(functional)	Functional	D	Supports Loss Of Function	3	submitted	EID13189 In a lung squamous cell carcinoma biopsy, split functional analysis of separated alleles in yeast (FASAY) identified TP53 Y205C (codon 205 TAT>TGT). Because codon 205 lies within the region shared by … (full text at CIViC) PMID 15161705 · Fouquet et al., 2004 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.