TP53 V157D

CI-VAR-00004461Explore in graph →CIViC 3574

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Neoplasm1
TP53 V157D	(oncogenic)	Oncogenic	D	Supports Oncogenicity	3	submitted	EID9784 A lung cancer patient was found to have TP53 V157D and PMS2 R20Q mutations in tumor tissue and distant normal lung tissue. These germline mutations were expressed alone or in combination in A549 lung … (full text at CIViC) PMID 23981578 · Wang et al., 2014 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.