SMARCB1 LOSS OF NUCLEAR PROTEIN EXPRESSION

CI-VAR-00002463Explore in graph →CIViC 3659

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Cribriform Neuroepithelial Tumor3
SMARCB1 LOSS OF NUCLEAR PROTEIN EXPRESSION	(diagnostic)	Diagnostic	C	Supports Positive	3	accepted	EID12327 This is the first case report of cribriform neuroepithelial tumor (CRINET), a rare brain cancer identified in a 26-month-old girl and a 10-month-old boy, affecting the third and fourth ventricles. His… (full text at CIViC) PMID 19915490 · Hasselblatt et al., 2009 · Open in CIViC	civic
SMARCB1 LOSS OF NUCLEAR PROTEIN EXPRESSION	(diagnostic)	Diagnostic	C	Supports Positive	3	accepted	EID12328 This study explored the molecular features of cribriform neuroepithelial tumors (CRINET) using multiplex ligation-dependent probe amplification (MLPA) and molecular inversion profiling (MIP) assays al… (full text at CIViC) PMID 26352987 · Gessi et al., 2015 · Open in CIViC

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.