Variant · Expression
SMARCA4 Underexpression
CI-VAR-00004404Explore in graph →CIViC 349
Curated evidence
Evidence by cancer (3 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 26671993
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Lung Non-Small Cell Carcinoma2 | ||||||||
| SMARCA4 Underexpression | (prognostic) | Prognostic | B | Supports Poor Outcome | 3 | accepted | EID838SMARCA4 expression was determined with gene expression microarray in 133 patients. Reduced overall survival was observed in patients with low SMARCA4 expression compared to intermediate (P<0 .001) or … (full text at CIViC) PMID 26671993 · Bell et al., 2016 · Open in CIViC | civic |
| SMARCA4 Underexpression | Cisplatin + VinorelbineCombination | Predictive | B | Supports Sensitivity Response | 3 | accepted | EID837SMARCA4 expression was determined with gene expression microarray in 133 patients. Improved five-year disease-specific survival (DSS) was noted only in patients with low SMARCA4 expression when treate… (full text at CIViC) PMID 26671993 · Bell et al., 2016 · | |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available