PTPN11 Glu76Lys

CI-VAR-00001864Explore in graph →CIViC 5487

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Neoplasm2
PTPN11 Glu76Lys	(oncogenic)	Oncogenic	D	Supports Oncogenicity	4	submitted	EID12996 PTPN11 (SHP2) p.Glu76Lys (NM_002834.5:c.226G>A) transforms primary murine myeloid cells. PMID 15710330 · Mohi et al., 2005 · Open in CIViC	civic
PTPN11 Glu76Lys	(oncogenic)	Oncogenic	D	Supports Oncogenicity	5	submitted	EID12997 PTPN11 p.Glu76Lys (NM_002834.5:c.226G>A) cause both basal and GM-CSF-stimulated hyperproliferation. PMID 15644411 · Chan et al., 2005 · Open in CIViC	civic
Unmapped disease1unmapped disease
PTPN11 Glu76Lys

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.