PTPN11 A461T

CI-VAR-00000102Explore in graph →CIViC 4248

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease1unmapped disease
PTPN11 A461T	(functional)	Functional	D	Supports Dominant Negative	3	submitted	EID10885 The LEOPARD syndrome associated mutation A461T is found in the protein-tyrosine phosphatase domain of Shp2 (encoded by PTPN11) and is predicted to affect catalysis. An assay to assess catalytic activi… (full text at CIViC) PMID 16377799 · Kontaridis et al., 2006 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.