Variant · Snv
PTEN T277R
CI-VAR-00004305Explore in graph →CIViC 3403
Curated evidence
Evidence by cancer (1 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 20712882
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Obsolete PTEN Hamartoma Tumor Syndrome1unmapped disease | ||||||||
| PTEN T277R | (predisposing) | Predisposing | C | N/A N/A | 1 | submitted | EID9469This retrospective study of 74 familial breast cancers was designed to identify new biomarkers of breast cancer in the background of early PTEN loss. A 27 year old female with invasive ductal carcinom… (full text at CIViC) PMID 20712882 · Banneau et al., 2010 · Open in CIViC | civic |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available
No ClinVar interpretation attached to this variant.