PTEN T277I

CI-VAR-00004304Explore in graph →CIViC 3406

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Obsolete PTEN Hamartoma Tumor Syndrome1unmapped disease
PTEN T277I	(predisposing)	Predisposing	C	N/A N/A	2	submitted	EID9472 A 4 year old female with macrocephaly and widespread capillary malformations was identified to have a de novo PTEN T277I (c.830C>T) variant (Patient 6). At birth she was noted to have a 46,XX karyotyp… (full text at CIViC) PMID 25549896 · Busa et al., 2015 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.