PTEN Expression

CI-VAR-00001034Explore in graph →CIViC 313

Curated evidence

Evidence by cancer (5 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–5 of 5 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Glioblastoma3
PTEN Expression	Dacomitinib	Predictive	D	Supports Sensitivity Response	2	accepted	EID775 In this preclinical study, the EGFR inhibitor dacomitinib had an effect on cell viability, self-renewal and proliferation in EGFR amplified GBM cells in-vitro and in-vivo (with or without the EGFRvIII… (full text at CIViC) PMID 25939761 · Zahonero et al., 2015 · Open in CIViC	civic
PTEN Expression	Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor	Predictive	B	Supports Sensitivity Response	4	accepted	EID774 49 patients (26 pretreatment tissues available for analysis) with recurrent glioblastomas who were treated with EGFR TKIs were analyzed in this study. Results were confirmed in an independent cohort o… (full text at CIViC) PMID 16282176 · Mellinghoff et al., 2005 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

HER2-Positive Breast Carcinoma1
PTEN Expression	Everolimus + FulvestrantCombination	Predictive	C	Supports Resistance	1	accepted	EID1624 Case report of a 44-year-old patient with recurrent HER2-positive breast cancer. The primary tumor was HR positive; however, the metastatic tumor was HR negative. The patient was resistant to classica… (full text at CIViC) PMID 27445490 · Sun et al., 2016 · Open in CIViC	civic

Malignant Breast Neoplasm1
PTEN Expression	Trastuzumab	Predictive	B	Supports Sensitivity Response	3	accepted	EID955 Trastuzumab was more effective in cell lines (SKBR3 vs. drug-resistant SKBR3/R) and 17 patient samples that exhibit elevated PTEN expression (by IHC). PMID 16404430 · Fujita et al., 2006 · Open in CIViC	civic