PTEN A121E

CI-VAR-00000047Explore in graph →CIViC 3544

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Glioma1
PTEN A121E AND NTRK1 ATRX	(diagnostic)	Diagnostic	B	Supports Positive	4	submitted	EID11495 Fusions involving neurotrophic tyrosine receptor kinase (NTRK) genes can promote gliomagenesis. While they varied in histological qualifications, nearly all the fused gliomas implicated a variant of t… (full text at CIViC) PMID 32665022 · Torre et al., 2020 · Open in CIViC	civic
Unmapped disease1unmapped disease
PTEN A121E	(functional)	Functional	D	Supports Loss Of Function	2	submitted	EID9740 Functional analysis of PTEN mutations was performed using an in vivo heterologous yeast reconstitution system to measure PTEN activity and rescue of growth arrest caused by hyperactive p110-alpha. The… (full text at CIViC) PMID 21828076 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.