PSMD4 Overexpression

CI-VAR-00003192Explore in graph →CIViC 2717

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Colorectal Neoplasm1
PSMD4 Overexpression	Carfilzomib	Predictive	D	Supports Sensitivity Response	3	submitted	EID7330 Nrf2 transfected colorectal cancer cells (shNrf2-HCT116) were found to have a 13.6 fold elevation in PSMD4, suggesting cytoplasmic Nrf2 leads to PSMD4 overexpression. Increased HIF-1a and nuclear B-c… (full text at CIViC) PMID 27033953 · Lin et al., 2016 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.