POLE R1233*

CI-VAR-00003638Explore in graph →CIViC 5210

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Endometrial Adenocarcinoma1
POLE R1233*	(oncogenic)	Oncogenic	C	Does Not Support Oncogenicity	2	submitted	EID12525 Studies submitted to cBioPortal (including 164 TCGA studies) were evaluated for POLE variants co-occurring with features of POLE-mutated tumors and co-occurring B2M variants. A single individual with … (full text at CIViC) PMID 29320758 · Voutsadakis, 2018 · Open in CIViC	civic
High-Grade Glioma, NOS1
POLE R1233*	(oncogenic)	Oncogenic	C	Does Not Support Oncogenicity	3	submitted	EID12524 A 14-year old patient with bi-allelic PMS2 pathogenic germline variants (c.2 T>A, p.M1K and c.2521del, p.W841Gfs*10) and a diagnosis of constitutional mismatch repair deficiency (CMMRD) was diagnosed … (full text at CIViC) PMID 38773265 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.