Variant · Deletion Cna
POLD1 Loss
CI-VAR-00417003Explore in graph →CIViC 5575
Curated evidence
Evidence by cancer (4 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-15
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 39128273
- Run
- ING-CIVIC-20260915-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Malignant Colorectal Neoplasm2 | ||||||||
| POLD1 Loss | ATR Inhibitor | Predictive | D | Supports Sensitivity Response | 4 | submitted | EID13255siRNA-mediated POLA1 protein depletion sensitized DLD-1 colorectal cancer cells to the ATR inhibitors ceralasertib (AZD6738) and berzosertib (VE-822), with approximately 9-fold and 4-fold shifts in IC… (full text at CIViC) PMID 39128273 · Schneider et al., 2024 · Open in CIViC | civic |
| POLD1 Loss | Chk1 Inhibitor | Predictive | D | Supports Sensitivity Response | 4 | submitted | EID13256siRNA-mediated POLA1 protein depletion sensitized DLD-1 colorectal cancer cells to the CHK1 inhibitors LY2603618 and MK-8776, producing approximately 6-fold and 8-fold shifts in IC50, respectively, re… (full text at CIViC) PMID 39128273 · Schneider et al., 2024 · Open in CIViC | |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available