PALB2 R414X

CI-VAR-00003851Explore in graph →CIViC 3463

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Breast Neoplasm1
PALB2 R414X	(prognostic)	Prognostic	C	Supports Poor Outcome	2	submitted	EID9581 Multi-gene cancer predisposition panel testing of a 51 year old patient diagnosed with breast cancer revealed a pathogenic PALB2 c.1240C>T, p.R414X variant. This patient had a family history of cancer… (full text at CIViC) PMID 26270727 · Desmond et al., 2015 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.