NF1 Q1336*

CI-VAR-00003484Explore in graph →CIViC 5546

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Melanoma1
NF1 Q1336*	Pan-RAF/MEK Molecular Glue NST-628	Predictive	D	Supports Sensitivity Response	4	submitted	EID13156 In NF1 Q1336*-mutant MeWo melanoma cells, NST-628 showed potent antiproliferative activity, increased apoptosis, and durably reduced MAPK-pathway signaling. In intracranial MeWo-luc xenografts, once-d… (full text at CIViC) PMID 38588399 · Ryan et al., 2024 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.