MIR21 Overexpression

CI-VAR-00003204Explore in graph →CIViC 2978

Curated evidence

Evidence by cancer (4 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–4 of 4 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Anaplastic Astrocytoma1
MIR21 Overexpression	(prognostic)	Prognostic	B	Supports Poor Outcome	3	submitted	EID8001 The expression of a set of miRNAs was evaluated by qRT-PCR in 124 astrocytoma (grade I-IV) samples and 60 adjacent normal tissue samples in order to determine miRNAs with altered expression in astrocy… (full text at CIViC) PMID 20219352 · Zhi et al., 2010 · Open in CIViC	civic
Glioma1
MIR21 Overexpression	(prognostic)	Prognostic	B	Supports Poor Outcome	3	submitted	EID8000 High expression of miR-21 was shown to be associated with worse OS (p<0.001) and PFS (p<0.001) in a Kaplan-Meier analysis of TCGA glioma dataset (n=641). Multivariate Cox regression analysis also show… (full text at CIViC) PMID 32144351 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Lung Non-Small Cell Carcinoma2
MIR21 Overexpression	Cisplatin	Predictive	B	Supports Resistance	3	submitted	EID8109 MIR21 expression was assessed in 58 NSCLC patient samples by real-time PCR. There was a significant association between MIR21 expression and platinum sensitivity (p=0.007). MIR21 expression was signif… (full text at CIViC) PMID 22237007 · Gao et al., 2012 · Open in CIViC	civic
MIR21 Overexpression	Cisplatin	Predictive	D	Supports Resistance	3	submitted	EID8110 MIR21 expression was assessed in 58 NSCLC patient samples by real-time PCR and a significant association between MIR21 expression and platinum sensitivity was found (p=0.007). To directly test the rol… (full text at CIViC) PMID 22237007 · Gao et al., 2012 · Open in CIViC	civic