Variant · Splice
MET Splice Site (c.3028+1G>A)
CI-VAR-00004201Explore in graph →NM_000245.4:c.3028+1G>AClinVar 976843 CIViC 4375
Curated evidence
Evidence by cancer (1 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 35860830
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Unmapped disease1unmapped disease | ||||||||
| MET Exon 14 Skipping Mutation AND ( MET Splice Site (c.3028+1G>T) OR MET Splice Site (c.3028+1G>A) OR MET Splice Site (c.3028+1G>C) ) | (functional) | Functional | B | Supports Gain Of Function | 3 | submitted | EID12831In this retrospective study, 564 NSCLC patients with somatic MET mutations were analyzed. There were 117 cases of METex14 skipping that were further sequenced. 75/117 cases (64.1%) affect the splicing… (full text at CIViC) PMID 35860830 · Ai et al., 2022 · Open in CIViC | civic |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available