Variant · Structural
MECOM rearrangement
CI-VAR-00005043Explore in graph →CIViC 5168
Curated evidence
Evidence by cancer (4 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-26
- Retrieved
- Sep 26, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- Run
- ING-CIVIC-20260926-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Acute Myeloid Leukemia1 | ||||||||
| MECOM rearrangement | (prognostic) | Prognostic | B | Supports Poor Outcome | 3 | submitted | EID13307This retrospective study from the I-BFM AML study group included 59 patients aged 0–21 years with de novo AML harboring a MECOM rearrangement (inv(3)/t(3;3) or other 3q26 rearrangements), diagnosed be… (full text at CIViC) | civic |
| Acute Myeloid Leukemia with MECOM Rearrangement3 | ||||||||
| MECOM rearrangement | (diagnostic) | Diagnostic | B | Supports Positive | 3 | accepted | EID12399In this study, 17 patients with a variant pericentric inv(3) were identified from an institutional cytogenetics database, out of283 myeloid neoplasms with a MECOM rearrangement (MECOM-R) confirmed b… (full text at CIViC) PMID 36672407 · Tang et al., 2023 · Open in CIViC | |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available