Variant · Structural
KMT2A Rearrangement
CI-VAR-00003960Explore in graph →CIViC 3141
Curated evidence
Evidence by cancer (4 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 31821784
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Acute Leukemia1 | ||||||||
| KMT2A Rearrangement | Menin Inhibitor + VTP50469Substitutes | Predictive | D | Supports Sensitivity Response | 5 | submitted | EID7819Patient-derived xenograft (PDX) models derived from patients with either MLL-r acute myeloid leukemia or MLL-r acute lymphoblastic leukemia (ALL) showed dramatic reductions of leukemia burden when tre… (full text at CIViC) PMID 31821784 · Krivtsov et al., 2019 · Open in CIViC | civic |
| Acute Lymphoblastic Leukemia1 | ||||||||
| KMT2A Rearrangement | (prognostic) | Prognostic | B | Supports Poor Outcome | 4 | submitted | EID8600KMT2A, also called MLL (MIXED- LINEAGE-LEUKAEMIA) gene is mapped to chromosome band 11q23, a region of recurrent rearrangements in acute leukemias. Collectively, acquired abnormalities in the 11q23 re… | |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available