KMT2A Mutation

CI-VAR-00002822Explore in graph →CIViC 4936

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Lung Non-Small Cell Carcinoma1
KMT2C Mutation OR KMT2D mutation OR KMT2A Mutation OR KMT2B Mutation	Immune Checkpoint Inhibitor	Predictive	B	Supports Sensitivity Response	2	submitted	EID12593 In a retrospective pan-cancer analysis of four immune checkpoint therapy (ICT)–treated cohorts (melanoma n = 287; NSCLC n = 131; total n = 418), KMT2 family mutations were associated with improved ICT… (full text at CIViC) PMID 33653367 · Zhang et al., 2021 · Open in CIViC	civic
Malignant Neoplasm1
KMT2C Mutation OR KMT2A Mutation	Immunotherapy	Predictive	B	Supports Sensitivity Response	4	accepted	EID12031 This study examined the role of KMT2A/C mutations as a potential biomarker for predicting the effectiveness of immunotherapy. In the primary ICI-treated cohort (n = 546), the researchers observed that…

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Melanoma1
KMT2C Mutation OR KMT2D mutation OR KMT2A Mutation OR KMT2B Mutation	Immune Checkpoint Inhibitor	Predictive	B	Supports Sensitivity Response	2	submitted	EID12592 In a retrospective pan-cancer analysis of four immune checkpoint therapy (ICT)–treated cohorts (melanoma n = 287; NSCLC n = 131; total n = 418), KMT2 family mutations were associated with improved ICT… (full text at CIViC) PMID 33653367 · Zhang et al., 2021 · Open in CIViC	civic