KIT V560DEL

CI-VAR-00004552Explore in graph →NP_000213.1:p.Val560delNM_000222.2:c.1675_1677delGTTClinVar 13859 CIViC 202

Curated evidence

Evidence by cancer (5 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–5 of 5 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Gastrointestinal Stromal Tumor3
KIT V560DEL	Imatinib	Predictive	D	Supports Sensitivity Response	—	submitted	EID2461 Molecular models predict that deletion of a portion of the juxtamembrane domain relieves steric hindrance and results in higher binding affinity for imatinib. PMID 21364689 · Pierotti et al., 2011 · Open in CIViC	civic
KIT V560DEL	Sunitinib	Predictive	C	Supports Resistance	—	submitted	EID4117 In a phase 1/2 trial of 97 gastrointestinal stromal tumor patients, patients with KIT exon 11 mutations (44/77) treated with sunitinib were associated with shorter progression free survival (5.1mo vs.… (full text at CIViC) PMID 18955458 · Heinrich et al., 2008 · Open in CIViC	civic
KIT V560DEL

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Thymus Carcinoma2
KIT V560DEL	Imatinib	Predictive	C	Supports Sensitivity Response	5	accepted	EID486 In a patient with thymic carcinoma, the tumor expressing an activating mutation in exon 11 of KIT (V560del) was sensitive to imatinib. PMID 15201427 · Ströbel et al., 2004 · Open in CIViC	civic
KIT V560DEL	Imatinib Mesylate	Predictive	C	Supports Sensitivity Response	3	submitted	EID7359 Thymic Carcinoma with Overexpression of Mutated KIT (V560DEL) and the Response to Imatinib PMID 15201427 · Ströbel et al., 2004 · Open in CIViC	civic