KIT T417_D419DELTYDINSI

CI-VAR-00004319Explore in graph →CIViC 1546

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Gastrointestinal Stromal Tumor1
KIT T417_D419DELTYDINSI	Sunitinib	Predictive	D	Supports Sensitivity Response	—	submitted	EID4584 In an in vitro study, a 32D cell line expressing KIT T417_D419del>I mutation (overexpression) demonstrated increased sensitivity to sunitinib treatment (IC50: 7.4nM) similar to 32D cells expressing KI… (full text at CIViC) PMID 24205792 · Zhao et al., 2014 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.