KIT F504A

CI-VAR-00001118Explore in graph →CIViC 3240

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease1unmapped disease
KIT F504A	(functional)	Functional	D	Does Not Support Gain Of Function	4	submitted	EID8965 This study described recurring, somatic oncogenic mutation located in the C-terminal Ig-like domain (D5) of the ectodomain rendering KIT tyrosine kinase constitutively active. Additional mutations in … (full text at CIViC) PMID 25544564 · Reshetnyak et al., 2015 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.