KIT D816F

CI-VAR-00000557Explore in graph →CIViC 4419

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Systemic Mastocytosis2
NOT KIT D816V AND ( KIT V560G OR KIT D816Y OR KIT D816F )	Imatinib Mesylate	Predictive	B	Supports Sensitivity Response	3	submitted	EID11163 In this phase IV clinical trial, ten patients with systemic mastocystosis (SM) were recruited to test efficacy and safety of imatinib. Nine patients fulfilled criteria for well-differentiated SM (WDSM… (full text at CIViC) PMID 28978170 · Alvarez-Twose et al., 2017 · Open in CIViC	civic
NOT KIT D816V AND ( KIT V560G OR KIT D816Y OR KIT D816F )	Imatinib Mesylate	Predictive	D	Supports Sensitivity Response	3	submitted	EID11162 In this preclinical study, two subclones of human mast cell leukemia line were used to investigate cellular response to KIT inhibitor STI571. HMC1.1 cell line expressing only the KIT V560G mutation an… (full text at CIViC) PMID 11861291 · Ma et al., 2002 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Unmapped disease1unmapped disease
NOT KIT D816V AND ( KIT V560G OR KIT D816Y OR KIT D816F )	(functional)	Functional	D	Supports Gain Of Function	2	submitted	EID11161 In this preclinical study, two subclones of human mast cell leukemia line were used to investigate cellular response to KIT inhibitor STI571. HMC1.1 cell line expressing only the KIT V560G mutation an… (full text at CIViC) PMID 11861291 · Ma et al., 2002 · Open in CIViC	civic