KIT D816E

CI-VAR-00000556Explore in graph →NP_000213.1:p.Asp816GluNM_000222.2:c.2448C>GClinVar 375929 CIViC 1559

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Gastrointestinal Stromal Tumor2
KIT D816E	Imatinib + SunitinibSubstitutes	Predictive	D	Supports Resistance	4	accepted	EID4631 Several preclinical studies were done in order to test the effects of various tyrosine kinase inhibitors (TKIs) on KIT-mutant cell lines derived from Gastrointestinal Stromal Tumor (GIST) patients wit… (full text at CIViC) PMID 25239608 · Garner et al., 2014 · Open in CIViC	civic
KIT D816E AND KIT V560_Y578del	Ponatinib	Predictive	D	Does Not Support Resistance	4	accepted	EID7401 A preclinical study was done in order to test the effects of a tyrosine kinase inhibitor (TKI) on the ponatinib-sensitive KIT-mutant cell line GIST-T1 derived from Gastrointestinal Stromal Tumor (GIST… (full text at CIViC) PMID 25239608 · Garner et al., 2014 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.