KDM6A R1213*

CI-VAR-00003636Explore in graph →CIViC 2645

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease1unmapped disease
KDM6A R1213*	(functional)	Functional	E	Supports Loss Of Function	3	submitted	EID7163 Mutations affecting the functional jumonji C (jmjC) domain of KDM6A inactivates its H3K27 demethylase activity 2 mutations occuring after the R1213* variant, p.C1234Y and p.W1319X, are driver mutation… (full text at CIViC) PMID 22377896 · Mar et al., 2012 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.