IDH1 R132Q

CI-VAR-00003659Explore in graph →CIViC 4433

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Chondrosarcoma2
IDH1 R132Q	(oncogenic)	Oncogenic	D	Supports Oncogenicity	3	rejected	EID11195 Conditional knock-in of IDH1 R132Q in chondrocytes in of weaned mice resulted in the development of multiple enchondroma-like lesions. Enchondromas are benign cartilage tumors and precursors to malig… (full text at CIViC) PMID 25730874 · Hirata et al., 2015 · Open in CIViC	civic
IDH1 R132Q	(oncogenic)	Oncogenic	D	Supports Oncogenicity	3	submitted	EID11196 Conditional knock-in of IDH1 R132Q in chondrocytes of weaned mice resulted in the development of multiple enchondroma-like lesions. Enchondromas are benign cartilage tumors and precursors to malignan… (full text at CIViC) PMID 25730874 · Hirata et al., 2015 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.