HSPH1 NUCLEAR EXPRESSION

CI-VAR-00002988Explore in graph →CIViC 490

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Gastric Adenocarcinoma2
HSPH1 NUCLEAR EXPRESSION	(prognostic)	Prognostic	B	Supports Poor Outcome	2	accepted	EID1162 HSP110 (HSPH1) expression was immunohistochemically assessed using a tissue microarray in 210 gastric cancer patients. The overall survival rate was significantly lower in patients with high nuclear e… (full text at CIViC) PMID 26943774 · Kimura et al., 2016 · Open in CIViC	civic
HSPH1 NUCLEAR EXPRESSION	Cisplatin + FluorouracilSubstitutes	Predictive	D	Supports Sensitivity Response	1	accepted	EID1163 49 patients gastric cancer patients treated with adjuvant chemotherapy were immunohistochemically assessed for nuclear HSPH1 (HSP110) expression. Overall survival rate in the high expression group (2+… (full text at CIViC) PMID 26943774 · Kimura et al., 2016 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.