FLT3 I836S

CI-VAR-00002028Explore in graph →NP_004110.2:p.Ile836SerNM_004119.3:c.2507T>GClinVar 376717 CIViC 3572

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Acute Myeloid Leukemia1
FLT3 I836S	(oncogenic)	Oncogenic	D	Supports Oncogenicity	2	accepted	EID9782 In this study, activating FLT3 mutations identified in patients with Acute Myeloid Leukemia were modeled using Ba/F3 cell lines generated by site-directed mutagenesis and transfection. These cells wer… (full text at CIViC) PMID 28077790 · Nguyen et al., 2017 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.