Variant · Snv
FGFR3 T450M
CI-VAR-00004322Explore in graph →NP_000133.1:p.Thr450MetNM_000142.5:c.1349C>TClinVar 134410 CIViC 4563
Curated evidence
Evidence by cancer (2 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 37980528
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Bladder Carcinoma1 | ||||||||
| FGFR3 T450M | (oncogenic) | Oncogenic | B | Does Not Support Oncogenicity | 2 | submitted | EID12596An Asian germline dataset (jMorp-14KJPN) was analyzed and five significantly enriched non-synonymous single nucleotide polymorphisms (SNPs) on the FGFR3 gene locus were found (Q29H, G65R, L164V, T450M… (full text at CIViC) PMID 37980528 · Komura et al., 2023 · Open in CIViC | civic |
| Malignant Lung Neoplasm1 | ||||||||
| FGFR3 T450M | (oncogenic) | Oncogenic | C | Supports Oncogenicity | 1 | submitted | EID12595In a set of 116 NSCLC tissues, 72 were tested for alterations in exons 7, 10, and 15 by sequencing. Sequencing of normal control tissue was not described. FGFR3 expression was also tested by IHC. From… (full text at CIViC) PMID 36794128 · | |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available