FGFR3 K650T

CI-VAR-00002163Explore in graph →NP_000133.1:p.Lys650ThrNM_000142.5:c.1949A>CClinVar 65855 CIViC 4021

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Bladder Neoplasm1
FGFR3 K650T	(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	submitted	EID10492 Targeted mutation analysis on the FGFR3 gene in 297 bladder cancer patients was conducted, where 177 patients were found to harbor FGFR3 mutations. Among those patients, one harbored the K650T variant… (full text at CIViC) PMID 12461689 · van Rhijn et al., 2002 · Open in CIViC	civic
Malignant Neoplasm1
FGFR3 K650T	(oncogenic)	Oncogenic	D	Supports Oncogenicity	1	submitted	EID12891 In a saturation mutagenesis study, all possible point mutations in the FGFR 1-4 kinase domain (amino acids 472-807 for FGFR3) were tested. Lentiviral plasmids were infected at MOI < 0.3 into the growt… (full text at CIViC) PMID 41361008 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Unmapped disease1unmapped disease
FGFR3 K650T	(functional)	Functional	D	Supports Gain Of Function	2	accepted	EID10382 FGFR3 cDNA construct with the K650T variant was synthesized and transfected into NIH3T3 cells. The K650T variant receptor had a 3.1-fold greater kinase activity compared to the wild type receptor in a… (full text at CIViC) PMID 11055896 · Bellus et al., 2000 · Open in CIViC	civic