FGFR3 K650M

CI-VAR-00002159Explore in graph →NP_000133.1:p.Lys650MetNM_000142.5:c.1949A>TClinVar 16341 CIViC 4013

Curated evidence

Evidence by cancer (4 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–4 of 4 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Bladder Neoplasm1
FGFR3 K650M	(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	submitted	EID10491 Targeted mutation analysis on the FGFR3 gene in 297 bladder cancer patients was conducted, where 177 patients were found to harbor FGFR3 mutations. Two patients were found to harbor the K650M variant … (full text at CIViC) PMID 12461689 · van Rhijn et al., 2002 · Open in CIViC	civic
Malignant Neoplasm1
FGFR3 K650M	(oncogenic)	Oncogenic	D	Supports Oncogenicity	1	submitted	EID12890 In a saturation mutagenesis study, all possible point mutations in the FGFR 1-4 kinase domain (amino acids 472-807 for FGFR3) were tested. Lentiviral plasmids were infected at MOI < 0.3 into the growt… (full text at CIViC) PMID 41361008 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Unmapped disease2unmapped disease
FGFR3 K650M	(functional)	Functional	D	Supports Gain Of Function	2	submitted	EID10369 In this study, authors investigated a K650M variant in FGFR3, which occurs within the receptor tyrosine kinase domain activation loop. The variant was found in four unrelated patients, whose clinical … (full text at CIViC) PMID 10053006 · Tavormina et al., 1999 · Open in CIViC	civic
FGFR3 K650M	(functional)	Functional	D	Supports Gain Of Function	2	accepted	EID10380 The K650M variant in FGFR3 is known to be responsible for the severe skeletal dysplasia forms seen in thanatophoric dysplasia type 1 / severe achondroplasia with developmental delay and acanthosis nig… (full text at CIViC) PMID 11055896 · Bellus et al., 2000 · Open in CIViC	civic