FGFR3 H274Y

CI-VAR-00001919Explore in graph →NP_000133.1:p.His274TyrNM_000142.5:c.820C>TCIViC 4038

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Neoplasm1
FGFR3 H274Y	(oncogenic)	Oncogenic	D	Does Not Support Oncogenicity	3	accepted	EID13186 In a moderate-throughput functional genomic screen, FGFR3 p.H274Y demonstrated cell proliferation and viability comparable to wild-type FGFR3 in growth factor-dependent Ba/F3 and/or MCF10A cellular as… (full text at CIViC) PMID 29533785 · Ng et al., 2018 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.