FGFR2 C491S

CI-VAR-00000317Explore in graph →CIViC 5556

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Lung Non-Small Cell Carcinoma1
FGFR2 C491S	Futibatinib	Predictive	D	Supports Resistance	4	submitted	EID13173 FGFR2 C491S was identified as selectively conferring futibatinib resistance in FGFR-dependent NCI-H1581 cells and was independently validated by drug-treated cell-viability and FGFR phosphorylation ex… (full text at CIViC) PMID 41361008 · Tangermann et al., 2025 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.