FGFR2 C342Y

CI-VAR-00000309Explore in graph →CIViC 3358

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease1unmapped disease
FGFR2 C342Y	(functional)	Functional	D	Supports Gain Of Function	3	submitted	EID9357 FGFR2 C342Y was expressed in rat chondrosarcoma chondrocytes and was shown to increase activation of ERK and LRP6 relative to wild-type, as measured by western blot. FGFR2 C342Y also caused increased … (full text at CIViC) PMID 22558232 · Krejci et al., 2012 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.