FGFR1 R189C

CI-VAR-00003744Explore in graph →CIViC 5490

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Neoplasm1
FGFR1 R189C	Tyrosine Kinase Inhibitor	Predictive	D	Supports Sensitivity Response	3	submitted	EID13000 Ziegler et al. evaluated FGFR1 R189C in NIH/3T3 mouse fibroblast models engineered with pMIGR1 retroviral constructs to express FGFR1 R189C or FGFR1 wild-type. FGFR variant constructs were generated b… (full text at CIViC) PMID 40526877 · Ziegler et al., 2025 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.