FBXW7 R465H

CI-VAR-00003859Explore in graph →CIViC 2647

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
T Acute Lymphoblastic Leukemia1
FBXW7 R465H	(predisposing)	Predisposing	D	Supports Predisposition	4	submitted	EID7174 In mouse models, constitutive NOTCH signaling contributes to the genesis of breast cancer, medulloblastoma, and T cell leukemia, whereas in human cancer its role is best exemplified by T cell acute ly… (full text at CIViC) PMID 17646409 · O'Neil et al., 2007 · Open in CIViC	civic
Unmapped disease1unmapped disease
FBXW7 R465H	(functional)	Functional	E	Supports Loss Of Function	3	rejected	EID7170 T-ALL mutations in FBXW7 are predominantly located at arginine residues R479Q, R505C, and R465H and result in FBXW7 mutants unable to bind to or degrade targets The R465H variant led to low levels of … (full text at CIViC)

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.