ETV6 R418G

CI-VAR-00003852Explore in graph →CIViC 3678

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease1unmapped disease
ETV6 R418G	(functional)	Functional	D	Supports Dominant Negative	4	submitted	EID10049 HEK293T cells were transfected with wild type (WT) or mutant (P214L, R418G, 385-418del) ETV6 along with a luciferase reporter construct of one of the ETV6 transcriptional target genes (stromelysin-1/M… (full text at CIViC) PMID 25807284 · Noetzli et al., 2015 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.