Variant · Deletion
ETV6 N385_R418del
CI-VAR-00002904Explore in graph →CIViC 3679
Curated evidence
Evidence by cancer (1 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 25807284
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Unmapped disease1unmapped disease | ||||||||
| ETV6 N385_R418del | (functional) | Functional | D | Supports Dominant Negative | 4 | submitted | EID10050HEK293T cells were transfected with wild type (WT) or mutant (P214L, R418G, 385-418del) ETV6 along with a luciferase reporter construct of one of the ETV6 transcriptional target genes (stromelysin-1/M… (full text at CIViC) PMID 25807284 · Noetzli et al., 2015 · Open in CIViC | civic |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available
No ClinVar interpretation attached to this variant.